Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly
نویسندگان
چکیده
منابع مشابه
Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein
The endosomal sorting complex required for transport (ESCRT) is a conserved protein complex that facilitates budding and fission of membranes. It executes a key step in many cellular events, including cytokinesis and multi-vesicular body formation. The ESCRT-III protein Shrub in flies, or its homologs in yeast (Snf7) or humans (CHMP4B), is a critical polymerizing component of ESCRT-III needed t...
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As you will see from their comments the referees express interest in the role of Vps25 in activating Vps20 and the requirement of two Snf7 oligomers for cargo sorting and request some further experimental analysis to make the study suitable for publication in the EMBO Journal. All the referees would like to see some further evidence for Snf7 oligomerisation in determining vesicle size, referee ...
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ژورنال
عنوان ژورنال: eLife
سال: 2019
ISSN: 2050-084X
DOI: 10.7554/elife.46207